Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation

Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly...

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Bibliographic Details
Published in:Microbiome 2017-03, Vol.5 (1), p.35-35, Article 35
Main Authors: Chua, Ling Ling, Rajasuriar, Reena, Azanan, Mohamad Shafiq, Abdullah, Noor Kamila, Tang, Mei San, Lee, Soo Ching, Woo, Yin Ling, Lim, Yvonne Ai Lian, Ariffin, Hany, Loke, P'ng
Format: Article
Language:English
Subjects:
Actinobacteria
Actinobacteria - genetics
Actinobacteria - isolation & purification
Adolescent
Adult
Anal Canal - microbiology
Bacteria - genetics
Bacteria - isolation & purification
Biodiversity
Biomarkers
C-Reactive Protein - analysis
Cancer therapies
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Chemotherapy
Corynebacterium
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 2 - etiology
Disease
DNA
Dysbiosis
Feces
Genetic testing
Healthy Volunteers
HLA-DR Antigens
Homeostasis
Humans
Immune response
Immune system
Inflammation
Interleukin-6 - immunology
Leukemia
Lymphocyte Activation - immunology
Lymphocytes T
Metabolism
Metabolites
Microbiota
Obesity - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Surveillance
Survivors
Thermal cycling
Transplants & implants
Young Adult
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Description
Summary:Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood. We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation. We demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.
ISSN:2049-2618
2049-2618
DOI:10.1186/s40168-017-0250-1