Outcomes in Patients with pT1-T2, pN0-N1 Breast Cancer After Conservative Surgery and Whole-breast Radiotherapy

To evaluate locoregional recurrence, overall survival, disease-free survival and prognostic influence of the number of positive lymph nodes and other variables in breast cancer treatment. A total of 377 patients with pT1-T2, pN0-N1 invasive breast carcinoma treated from 2005 to 2013 were retrospecti...

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Bibliographic Details
Published in:In vivo (Athens) 2017-01, Vol.31 (1), p.151-158
Main Authors: Trignani, Marianna, DI Carlo, Clelia, Cefalogli, Carmen, Nuzzo, Marianna, Ursini, Lucia Anna, Caravatta, Luciana, Perrotti, Francesca, DI Nicola, Marta, Pamio, Ambra, Genovesi, Domenico
Format: Article
Language:English
Subjects:
Adult
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Combined Modality Therapy
Female
Humans
Mastectomy - mortality
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant - mortality
Retrospective Studies
Survival Rate
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Summary:To evaluate locoregional recurrence, overall survival, disease-free survival and prognostic influence of the number of positive lymph nodes and other variables in breast cancer treatment. A total of 377 patients with pT1-T2, pN0-N1 invasive breast carcinoma treated from 2005 to 2013 were retrospectively evaluated. Patients underwent conservative surgery followed by whole-breast radiotherapy. Clavicular region irradiation was not performed. With a median follow-up of 4 years, locoregional recurrence rate was 3.4% (nodal recurrence=1.06%). Expression of progesterone receptors was significantly associated with better disease-free survival, tumor size (T>2 cm) with poorer disease-free survival, locoregional recurrence and poorer overall survival; the presence of three nodal metastases was related to significantly poorer overall survival (p=0.024). Whole-breast adjuvant radiotherapy without nodal irradiation after breast-conserving surgery led to low rate of locoregional recurrence and high rates of overall survival and disease-free survival in patients with pT1-T2 pN0-N1 breast cancer.
ISSN:1791-7549
0258-851X
1791-7549
DOI:10.21873/invivo.11039