BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers

Here, BTG1 overexpression inhibited proliferation, induced differentiation, autophagy, and apoptosis in colorectal cancer cells (p

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Bibliographic Details
Published in:Oncotarget 2017-01, Vol.8 (5), p.7502-7520
Main Authors: Zhao, Shuang, Chen, Shu-Rui, Yang, Xue-Feng, Shen, Dao-Fu, Takano, Yasuo, Su, Rong-Jian, Zheng, Hua-Chuan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Autophagy
beta Catenin - metabolism
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Differentiation
Cell Proliferation
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Dose-Response Relationship, Drug
Female
G2 Phase Cell Cycle Checkpoints
Gene Expression Regulation, Neoplastic
Genetic Therapy - methods
HCT116 Cells
Humans
Mice, Inbred BALB C
Mice, Nude
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
Research Paper
Signal Transduction
Time Factors
Transfection
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Description
Summary:Here, BTG1 overexpression inhibited proliferation, induced differentiation, autophagy, and apoptosis in colorectal cancer cells (p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.10649