Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise

The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well...

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Bibliographic Details
Published in:Physiological reports 2017-03, Vol.5 (5), p.np-n/a
Main Authors: Lee, Sindre, Norheim, Frode, Gulseth, Hanne L., Langleite, Torgrim M., Kolnes, Kristoffer J., Tangen, Daniel S., Stadheim, Hans K., Gilfillan, Gregor D., Holen, Torgeir, Birkeland, Kåre I., Jensen, Jørgen, Drevon, Christian A.
Format: Article
Language:eng ; nor
Subjects:
Adipocytes
Adiponectin
Adiponectin - blood
Adipose tissue
Adipose Tissue and Obesity
alpha-2-HS-Glycoprotein - metabolism
Biopsy
Blood Glucose - metabolism
Clinical trials
Cytokines
Endocrine and Metabolic Conditons, Disorders and Treatments
Endurance
Endurance and Performance
Exercise
Exercise - physiology
Fatty acids
Fatty Acids, Nonesterified - blood
fetuin‐A
free fatty acids
Gene expression
Glucose
Glucose Clamp Technique
hepatokine
human
Humans
Immunology
Inflammation
Insulin
Insulin resistance
Insulin Resistance - physiology
insulin sensitivity
Kinases
Leptin
Leptin - blood
Lipids
Liver
Macrophages
Male
Metabolism
Middle Aged
Muscle, Skeletal - physiology
Musculoskeletal system
National libraries
Obesity
Original Research
Physical Endurance - physiology
Physiology
Resistance Training
Secretion
Signalling Pathways
Skeletal muscle
Studies
TLR4 protein
Toll-Like Receptor 4 - metabolism
Toll-like receptors
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Summary:The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well documented if some of the beneficial effects of exercise can be explained by altered secretion of hepatokines. The aim of this study was to examine the effect of interaction between fetuin‐A and FFAs on insulin sensitivity after physical exercise. In this study, 26 sedentary men who underwent 12 weeks of combined endurance and strength exercise were included. Insulin sensitivity was measured using euglycemic‐hyperinsulinemic clamp, and AT insulin resistance was indicated by the product of fasting plasma concentration of FFAs and insulin. Blood samples and biopsies from skeletal muscle and subcutaneous AT were collected. Several phenotypic markers were measured, and mRNA sequencing was performed on the biopsies. AT macrophages were analyzed based on mRNA markers. The intervention improved hepatic parameters, reduced plasma fetuin‐A concentration (~11%, P 
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.13183