Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model

In a novel animal model Octodon degus we tested the hypothesis that, in addition to genetic predisposition, early life stress (ELS) contributes to the etiology of attention-deficit hyperactivity disorder-like behavioral symptoms and the associated brain functional deficits. Since previous neurochemi...

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Bibliographic Details

Published in:	Brain Structure and Function 2017-03, Vol.222 (2), p.765-780
Main Authors:	Bock, J., Breuer, S., Poeggel, G., Braun, K.
Format:	Article
Language:	eng
Subjects:	Anatomy & physiology Animals Attention - drug effects Attention Deficit Disorder with Hyperactivity - etiology Attention Deficit Disorder with Hyperactivity - physiopathology Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Brain - physiopathology Cell Biology Disease Models, Animal Dopamine Uptake Inhibitors - administration & dosage Hyperactivity Impulsive Behavior - drug effects Methylphenidate - administration & dosage Motor Activity - drug effects Neurochemistry Neurology Neurosciences Octodon Octodon degus Original Original Article Rats Stress response Stress, Psychological - complications Stress, Psychological - metabolism Stress, Psychological - psychology
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