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In vivo photoacoustic lipid imaging in mice using the second near-infrared window
Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical imaging by providing users with label-free optical contrast of tissue. Here, we present a proof-of-concept study for noninvasive murine lipid imaging using 1210 nm light to investigate differences in peria...
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Published in: | Biomedical optics express 2017-02, Vol.8 (2), p.736-742 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical imaging by providing users with label-free optical contrast of tissue. Here, we present a proof-of-concept study for noninvasive
murine lipid imaging using 1210 nm light to investigate differences in periaortic fat among mice of different gender, genotypes, and maturation. Acquired lipid signals suggest that adult male apoE
mice have greater periaortic fat accumulation compared to adolescent males, apoE
females, and wild-type mice. These results demonstrate the potential of photoacoustic tomography for studying vascular pathophysiology and improving the diagnosis of lipid-based diseases. |
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ISSN: | 2156-7085 2156-7085 |
DOI: | 10.1364/boe.8.000736 |