Manipulation of Pluripotent Stem Cell Metabolism for Clinical Application

Purpose of review Pluripotent stem cells (PSCs) have the capacity to differentiate into various types of cells, and are promising cell sources for regenerative therapy and drug screening. However, to realize the clinical application of PSCs, a large number of highly qualified target cells must be st...

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Bibliographic Details
Published in:Current stem cell reports 2017-03, Vol.3 (1), p.28-34
Main Authors: Tohyama, Shugo, Tanosaki, Sho, Someya, Shota, Fujita, Jun, Fukuda, Keiichi
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cell Biology
Cell differentiation
Cell self-renewal
Cell survival
Drug screening
Gene Therapy
Immunology
Life Sciences
Metabolism
Metabolism and Stem Cells (D Nakada
Metabolism and Stem Cells (D Nakada, Section Editor)
Pluripotency
Section Editor
Stem Cells
Topical Collection on Metabolism and Stem Cells
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Summary:Purpose of review Pluripotent stem cells (PSCs) have the capacity to differentiate into various types of cells, and are promising cell sources for regenerative therapy and drug screening. However, to realize the clinical application of PSCs, a large number of highly qualified target cells must be stably prepared with low cost. To achieve this, great improvements in the reprogramming, differentiation, and elimination of residual PSCs will be necessary. In this review, we summarize the updated knowledge about metabolism in PSCs and its application. Recent findings Recent studies have shown that PSCs have distinct metabolic profiles compared to differentiated cells. The metabolic profiles of PSCs are indispensable for the maintenance of pluripotency, self-renewal, differentiation capacity, and cell survival. Summary Metabolic approaches show improved simplicity, scalability, and lower cost than conventional methods for differentiation and elimination of residual PSCs. Thus, manipulation of PSC metabolism will lead to new technologies to improve their efficiencies.
ISSN:2198-7866
2198-7866
DOI:10.1007/s40778-017-0073-9