Exploring the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme patients by a novel survival analysis model
This study is to explore the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme (GBM) patients. Our results not only showed that mutually explored GBM survival time related genes and signaling transduction pathways are closely related to the GBM, bu...
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Published in: | BMC genomics 2017-01, Vol.18 (Suppl 1), p.950-950, Article 950 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | This study is to explore the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme (GBM) patients.
Our results not only showed that mutually explored GBM survival time related genes and signaling transduction pathways are closely related to the GBM, but also demonstrated that our innovated constrained optimization algorithm (CoxSisLasso strategy) are better than the classical methods (CoxLasso and CoxSis strategy).
We analyzed why the CoxSisLasso strategy can outperform the existing classical methods and discuss how to extend this research in the distant future. |
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ISSN: | 1471-2164 1471-2164 |