Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles

Background Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2017-02, Vol.34 (2), p.191-200
Main Authors: Luke, Barbara, Brown, Morton B., Wantman, Ethan, Stern, Judy E., Toner, James P., Coddington, Charles C.
Format: Article
Language:English
Subjects:
Assisted Reproduction Technologies
Birth Weight
Body mass index
Clinics
Cryopreservation
Embryo Transfer - methods
Embryos
Female
Fertilization in Vitro - methods
Freezing
Gestational Age
Gynecology
Human Genetics
Humans
In vitro fertilization
Infant, Low Birth Weight
Infant, Newborn
Infertility
Medicine
Medicine & Public Health
Multiple births
Obstetrics
Pregnancy
Pregnancy Outcome
Premature Birth
Reproductive health
Reproductive Medicine
Reproductive Techniques, Assisted
Reproductive technologies
Siblings
Society
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Summary:Background Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage. Methods Pairs of singleton births conceived with IVF and born between 2004 and 2013 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, matched for embryo stage (blastocyst versus non-blastocyst) and infant gender, categorized by embryo state (fresh versus frozen) in 1st and 2nd births (four groups). Results The data included 7795 singleton pairs. Birthweight z-scores were 0.00–0.04 and 0.24–0.26 in 1st and 2nd births in fresh cycles, and 0.25–0.34 and 0.50–0.55 in frozen cycles, respectively. LGA was 9.2–9.8 and 14.2–15.4% in 1st and 2nd births in fresh cycles, and 13.1–15.8 and 20.8–21.0% in 1st and 2nd births in frozen cycles. The risk of LGA was increased in frozen cycles (1st births, adjusted odds ratios (AOR) 1.74, 95% CI 1.45, 2.08; and in 2nd births when the 1st birth was not LGA, AOR 1.70, 95% CI 1.46, 1.98 for fresh/frozen and 1.40, 1.11, 1.78 for frozen/frozen). Conclusions Our results with siblings indicate that frozen embryo state is associated with an increased risk for LGA. The implications of these findings for childhood health and risk of obesity are unclear, and warrant further investigation.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-016-0850-x