No effect of mitochondrial genotype on reproductive plasticity following exposure to a non-infectious pathogen challenge in female or male Drosophila

Mitochondrial genetic variation shapes the expression of life-history traits associated with reproduction, development and survival, and has also been associated with the prevalence and progression of infectious bacteria and viruses in humans. The breadth of these effects on multifaceted components...

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Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42009-42009, Article 42009
Main Authors: Nystrand, M, Cassidy, E J, Dowling, D K
Format: Article
Language:English
Subjects:
Animal reproduction
Animals
Bacteria - pathogenicity
Breeding success
Drosophila - genetics
Drosophila - microbiology
Drosophila - physiology
Female
Genetic diversity
Genome, Mitochondrial
Genotype
Haplotypes
Immune system
Insects
Life history
Life History Traits
Male
Mitochondria
Pathogens
Plasticity
Polymorphism, Genetic
Reproduction
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Summary:Mitochondrial genetic variation shapes the expression of life-history traits associated with reproduction, development and survival, and has also been associated with the prevalence and progression of infectious bacteria and viruses in humans. The breadth of these effects on multifaceted components of health, and their link to disease susceptibility, led us to test whether variation across mitochondrial haplotypes affected reproductive success following an immune challenge in the form of a non-infectious pathogen. We test this, by challenging male and female fruit flies (Drosophila melanogaster), harbouring each of three distinct mitochondrial haplotypes in an otherwise standardized genetic background, to either a mix of heat-killed bacteria, or a procedural control, prior to measuring their subsequent reproductive performance. The effect of the pathogen challenge on reproductive success did not differ across mitochondrial haplotypes; thus there was no evidence that patterns of reproductive plasticity were modified by the mitochondrial genotype following a non-infectious pathogen exposure. We discuss the implications of our data, and suggest future research avenues based on these results.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42009