The Role of MicroRNAs and Their Targets in Osteoarthritis

Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore,...

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Bibliographic Details
Published in:Current rheumatology reports 2016-08, Vol.18 (8), p.56-56, Article 56
Main Authors: Sondag, Gregory R., Haqqi, Tariq M.
Format: Article
Language:English
Subjects:
Cartilage, Articular - metabolism
Inflammation - genetics
Inflammation - metabolism
Intracellular Signaling Peptides and Proteins
Medicine
Medicine & Public Health
MicroRNAs - genetics
MicroRNAs - metabolism
Osteoarthritis (MB Goldring
Osteoarthritis - genetics
Osteoarthritis - metabolism
Rheumatology
Section Editor
Topical Collection on Osteoarthritis
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Summary:Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationships of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify certain microRNAs that are differentially expressed in osteoarthritis but have unidentified targets and functions in the disease state. Lastly, we identify the potential use of microRNAs for therapeutic purposes and also mention certain remedies that regulate microRNA expression.
ISSN:1523-3774
1534-6307
DOI:10.1007/s11926-016-0604-x