Lipids, lipoprotein distribution and depressive symptoms: the Multi-Ethnic Study of Atherosclerosis

Previous studies suggest lower concentrations of total and high-density lipoprotein (HDL) cholesterol to be predictive of depression. We therefore investigated the relationship of lipids and lipoprotein distribution with elevated depressive symptoms (EDS) in healthy men and women from the Multi-Ethn...

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Bibliographic Details
Published in:Translational psychiatry 2016-11, Vol.6 (11), p.e962-e962
Main Authors: Ong, K L, Morris, M J, McClelland, R L, Maniam, J, Allison, M A, Rye, K-A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atherosclerosis - blood
Atherosclerosis - ethnology
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
Depressive Disorder - blood
Depressive Disorder - ethnology
Female
Follow-Up Studies
Humans
Lipids - blood
Lipoproteins - blood
Magnetic Resonance Spectroscopy
Male
Middle Aged
Original
Risk Factors
Statistics as Topic
Triglycerides - blood
United States
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Summary:Previous studies suggest lower concentrations of total and high-density lipoprotein (HDL) cholesterol to be predictive of depression. We therefore investigated the relationship of lipids and lipoprotein distribution with elevated depressive symptoms (EDS) in healthy men and women from the Multi-Ethnic Study of Atherosclerosis (MESA). Participants were followed up over a 9.5-year period. EDS were defined as a Center for Epidemiological Studies Depression (CES-D) score ⩾16 and/or use of antidepressant drugs. Lipoprotein distribution was determined from plasma using nuclear magnetic resonance spectroscopy. Among 4938 MESA participants (mean age=62 years) without EDS at baseline, 1178 (23.9%) developed EDS during follow-up. In multivariable Cox regression analyses, lower total, low-density lipoprotein (LDL) and non-HDL cholesterol concentrations at baseline were associated with incident EDS over 9.5 years (hazards ratio (HR)=1.11-1.12 per s.d. decrease, all P
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2016.232