Multiple Rare Variants in Different Genes Account for Multifactorial Inherited Susceptibility to Colorectal Adenomas

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for

Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS 2004-11, Vol.101 (45), p.15992-15997
Main Authors:	Fearnhead, Nicola S., Wilding, Jennifer L., Winney, Bruce, Tonks, Susan, Bartlett, Sylvia, Bicknell, David C., Ian P. M. Tomlinson, Neil J. Mc C. Mortensen, Bodmer, Walter F.
Format:	Article
Language:	eng
Subjects:	Adenoma Adenoma - genetics Adenomatous polyps Alleles Axin Protein Base Pair Mismatch Base Sequence Biological Sciences Case-Control Studies Cell lines Colorectal cancer Colorectal Neoplasms - genetics DNA Mutational Analysis DNA repair DNA Repair - genetics DNA, Neoplasm - genetics Exons Gene Frequency Genes Genes, APC Genetic inheritance Genetic mutation Genetic Variation Germ-Line Mutation Heredity Humans Microsatellite Repeats Microsatellites Models, Genetic Polymerase chain reaction Polymorphism Repressor Proteins - genetics Signal Transduction - genetics
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