Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Rheumatoid arthritis (RA) is a progressive disease that affects both pediatric and adult populations. The cellular basis for RA has been investigated extensively using animal models, human tissues and isolated cells in culture. However, many aspects of its aetiology and molecular mechanisms remain u...

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Bibliographic Details
Published in:The Journal of physiology 2017-02, Vol.595 (3), p.635-645
Main Authors: Clark, R. B., Schmidt, T. A., Sachse, F. B., Boyle, D., Firestein, G. S., Giles, W. R.
Format: Article
Language:English
Subjects:
[Ca2+]i
Animals
Ca2+‐activated K+ current
Cellular and Molecular Conditions, Disorders and Treatments
Cellular and Molecular Physiology
depolarization ‐ secretion coupling
Electrophysiological Phenomena
Fibroblasts
Fibroblasts - physiology
Humans
IK‐Ca
Intracellular calcium
inward rectifier K+ currents
ion channels
Ion Channels - physiology
Membrane Physiology
patch clamp
Principles
resting potential
Rodents
synovial fibroblasts
Synovial Membrane - cytology
Topical Review
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Summary:Rheumatoid arthritis (RA) is a progressive disease that affects both pediatric and adult populations. The cellular basis for RA has been investigated extensively using animal models, human tissues and isolated cells in culture. However, many aspects of its aetiology and molecular mechanisms remain unknown. Some of the electrophysiological principles that regulate secretion of essential lubricants (hyaluronan and lubricin) and cytokines from synovial fibroblasts have been identified. Data sets describing the main types of ion channels that are expressed in human synovial fibroblast preparations have begun to provide important new insights into the interplay among: (i) ion fluxes, (ii) Ca2+ release from the endoplasmic reticulum, (iii) intercellular coupling, and (iv) both transient and longer duration changes in synovial fibroblast membrane potential. A combination of this information, knowledge of similar patterns of responses in cells that regulate the immune system, and the availability of adult human synovial fibroblasts are likely to provide new pathophysiological insights.
ISSN:0022-3751
1469-7793
DOI:10.1113/JP270209