Macrolide resistance mechanisms and virulence factors in erythromycin-resistant Campylobacter species isolated from chicken and swine feces and carcasses

Resistance to antimicrobials was measured in 73 isolates of Campylobacter jejuni (C. jejuni) and 121 isolates of Campylobacter coli (C. coli) from chicken and swine feces and carcasses in Korea. Both bacterial species showed the highest resistance to (fluoro) quinolones (ciprofloxacin and nalidixic...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2016, Vol.78(12), pp.1791-1795
Main Authors: LIM, Suk-Kyung, MOON, Dong-Chan, CHAE, Myung Hwa, KIM, Hae Ji, NAM, Hyang-Mi, KIM, Su-Ran, JANG, Gum-Chan, LEE, Kichan, JUNG, Suk-Chan, LEE, Hee-Soo
Format: Article
Language:English
Subjects:
Amino acids
Animals
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Antimicrobial resistance
Bacteria
Campylobacter
Campylobacter coli - drug effects
Campylobacter coli - genetics
Campylobacter coli - isolation & purification
Campylobacter jejuni - drug effects
Campylobacter jejuni - genetics
Campylobacter jejuni - isolation & purification
Carcasses
Chickens - microbiology
Ciprofloxacin
Drug Resistance, Bacterial - genetics
Erythromycin
Erythromycin - pharmacology
Feces
Feces - microbiology
Fluoroquinolones
Food
Livestock
macrolide resistance
Macrolides - pharmacology
Meat - microbiology
Microbial Sensitivity Tests
Mutation
Nalidixic acid
Pathogens
Point Mutation
Poultry
Proteins
Public Health
Quinolones
Republic of Korea
Resistance factors
Ribosomal proteins
RNA, Ribosomal, 23S - genetics
rRNA
rRNA 23S
Swine
Swine - microbiology
virulence factor
Virulence factors
Virulence Factors - genetics
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Summary:Resistance to antimicrobials was measured in 73 isolates of Campylobacter jejuni (C. jejuni) and 121 isolates of Campylobacter coli (C. coli) from chicken and swine feces and carcasses in Korea. Both bacterial species showed the highest resistance to (fluoro) quinolones (ciprofloxacin and nalidixic acid) out of the nine antimicrobials tested. Erythromycin resistance was much higher in C. coli (19.0%, 23/121) than in C. jejuni (6.8%, 5/73). The mutation in the 23S rRNA gene was primarily responsible for macrolide resistance in Campylobacter isolates. Several amino acid substitutions in the L4 and L22 ribosomal proteins may play a role in the mechanism of resistance, but the role requires further evaluation. A total of eight virulence genes were detected in 28 erythromycin-resistant Campylobacter isolates. All C. jejuni isolates carried more than four such genes, while C. coli isolates carried fewer than three such genes. The high rate of resistance highlights the need to employ more prudent use of critically important antimicrobials, such as fluoroquinolones and macrolides, in swine and poultry production, and to more carefully monitor antimicrobial resistance in Campylobacter isolates in food animals.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.16-0307