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Azole Antifungal Resistance in Candida albicans and Emerging Non- albicans Candida Species
Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat infections. Azole antifungals such as fluconazole are often preferred treatment for many infections as they are inexpensive, exhibit limited toxicity, and are available for oral administratio...
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Published in: | Frontiers in microbiology 2017-01, Vol.7, p.2173-2173 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat
infections. Azole antifungals such as fluconazole are often preferred treatment for many
infections as they are inexpensive, exhibit limited toxicity, and are available for oral administration. There is, however, extensive documentation of intrinsic and developed resistance to azole antifungals among several
species. As the frequency of azole resistant
isolates in the clinical setting increases, it is essential to elucidate the mechanisms of such resistance in order to both preserve and improve upon the azole class of antifungals for the treatment of
infections. This review examines azole resistance in infections caused by
as well as the emerging non-
species
, and
and in particular, describes the current understanding of molecular basis of azole resistance in these fungal species. |
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ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2016.02173 |