Loading…
The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties
Background/Objectives: The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity. Subjects/Methods: Seventy-five young (18–49 yrs) an...
Saved in:
| Published in: | International Journal of Obesity 2017-01, Vol.41 (1), p.102-111 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743 |
| container_end_page | 111 |
| container_issue | 1 |
| container_start_page | 102 |
| container_title | International Journal of Obesity |
| container_volume | 41 |
| creator | Erskine, R M Tomlinson, D J Morse, C I Winwood, K Hampson, P Lord, J M Onambélé, G L |
| description | Background/Objectives:
The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity.
Subjects/Methods:
Seventy-five young (18–49 yrs) and 67 older (50–80 yrs) healthy, untrained men and women (BMI: 17–49 kg/m
2
) performed isometric and isokinetic plantar flexor maximum voluntary contractions (MVCs). Volume (
V
m
), fascicle pennation angle (FPA), and physiological cross-sectional area (PCSA) of the
gastrocnemius medialis
(GM) muscle were measured using ultrasonography. Voluntary muscle activation (VA) was assessed using electrical stimulation. GM specific force was calculated as GM fascicle force/PCSA. Percentage body fat (BF%), body fat mass (BFM), and lean mass (BLM) were assessed using dual-energy X-ray absorptiometry. Serum concentration of 12 cytokines was measured using multiplex luminometry.
Results:
Despite greater
V
m
, FPA, and PCSA (
P |
| doi_str_mv | 10.1038/ijo.2016.151 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5220159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476578573</galeid><sourcerecordid>A476578573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743</originalsourceid><addsrcrecordid>eNqNks1r3DAQxU1paTZpbz0XQ6HkUG8lW5LlSyCEfkGgl_QsZHm0q60sbS07sNA_vuNsuuyWHIoEAuk3j9Gbl2VvKFlSUsmPbhOXJaFiSTl9li0oq0XBWVM_zxakInVBuOBn2XlKG0II56R8mZ2VNReNkHSR_b5bQ-5C5-5dN2mf69DlJvatC9DlYC2YMeXR5rGF5MZd8QDoFbiwKrBsMoilXRqhdwZ1rNd9r0cXQ457PfU65OkneBhRu5-S8ZBvh7iFYXSQXmUvrPYJXj-eF9mPz5_ubr4Wt9-_fLu5vi0Ml3QsGmObhghqaNuCoYZAJ7qGsYoxqSXQVoIwFVheyrLlmlvBqGW05F0lBatZdZFd7XW3U9tDZyCMg_ZqO7heDzsVtVOnL8Gt1SreK16is7xBgctHgSH-miCNqnfJgPc6QJySopI3TNJS_hfKiajqh7be_YNu4jQEdGKmUK8ROOEDtdIeFFocsUUzi6prnDWvJa8rpJZPULi6eTIxgHV4f1Lw_qhgDdqP6xT9NM8unYIf9qAZYkoD2INvlKg5gQoTqOYEKkwg4m-PvT7AfyOHQLEHEj6FFQxHv35K8A9_tOWB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1854819610</pqid></control><display><type>article</type><title>The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties</title><source>Springer Link</source><source>Nature Journals Online</source><creator>Erskine, R M ; Tomlinson, D J ; Morse, C I ; Winwood, K ; Hampson, P ; Lord, J M ; Onambélé, G L</creator><creatorcontrib>Erskine, R M ; Tomlinson, D J ; Morse, C I ; Winwood, K ; Hampson, P ; Lord, J M ; Onambélé, G L</creatorcontrib><description>Background/Objectives:
The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity.
Subjects/Methods:
Seventy-five young (18–49 yrs) and 67 older (50–80 yrs) healthy, untrained men and women (BMI: 17–49 kg/m
2
) performed isometric and isokinetic plantar flexor maximum voluntary contractions (MVCs). Volume (
V
m
), fascicle pennation angle (FPA), and physiological cross-sectional area (PCSA) of the
gastrocnemius medialis
(GM) muscle were measured using ultrasonography. Voluntary muscle activation (VA) was assessed using electrical stimulation. GM specific force was calculated as GM fascicle force/PCSA. Percentage body fat (BF%), body fat mass (BFM), and lean mass (BLM) were assessed using dual-energy X-ray absorptiometry. Serum concentration of 12 cytokines was measured using multiplex luminometry.
Results:
Despite greater
V
m
, FPA, and PCSA (
P
<0.05), young individuals with BF% ⩾40 exhibited 37% less GM specific force compared to young BF%<40 (
P
<0.05). Older adults with BF% ⩾40 showed greater isokinetic MVC compared to older BF%<40 (
P
=0.019) but this was reversed when normalised to body mass (
P
<0.001). IL-6 correlated
inversely
with VA in young (
r
=−0.376;
P
=0.022) but not older adults (
p>
0.05), while IL-8 correlated with VA in older but not young adults (
r
⩾0.378,
P
⩽0.027). TNF-alpha correlated with MVC, lean mass, GM FPA and maximum force in older adults (
r
⩾0.458;
P
⩽0.048).
Conclusions:
The age- and adiposity-dependent relationships found here provide evidence that circulating pro-inflammatory cytokines may play different roles in muscle remodelling according to the age and adiposity of the individual.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2016.151</identifier><identifier>PMID: 27569681</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/1 ; 13/21 ; 631/250/127 ; 631/443/7 ; 692/163/2743/393 ; 692/4023/1671/1668/1973 ; Absorptiometry, Photon ; Adiposity - physiology ; Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Aging ; Aging - metabolism ; Aging - physiology ; Biomechanical Phenomena ; Body fat ; Body mass index ; Cytokines ; Cytokines - metabolism ; Epidemiology ; Female ; Health aspects ; Health care ; Health Promotion and Disease Prevention ; Humans ; Hypothalamus ; Inflammation ; Inflammation - etiology ; Inflammation - metabolism ; Inflammation - physiopathology ; Internal Medicine ; Isometric Contraction ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Muscle strength ; Muscle Strength - physiology ; Muscle Strength Dynamometer ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Musculoskeletal system ; Obesity ; Obesity - complications ; Obesity - metabolism ; Obesity - physiopathology ; Older people ; Original ; original-article ; Physiological aspects ; Physiology ; Public Health ; Quality of life ; Reproducibility of Results ; Risk factors ; Skeletal muscle ; Tumor necrosis factor-TNF ; Young Adult ; Young adults</subject><ispartof>International Journal of Obesity, 2017-01, Vol.41 (1), p.102-111</ispartof><rights>The Author(s) 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature. 2017 Macmillan Publishers Limited, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743</citedby><cites>FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,783,787,888,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27569681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erskine, R M</creatorcontrib><creatorcontrib>Tomlinson, D J</creatorcontrib><creatorcontrib>Morse, C I</creatorcontrib><creatorcontrib>Winwood, K</creatorcontrib><creatorcontrib>Hampson, P</creatorcontrib><creatorcontrib>Lord, J M</creatorcontrib><creatorcontrib>Onambélé, G L</creatorcontrib><title>The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives:
The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity.
Subjects/Methods:
Seventy-five young (18–49 yrs) and 67 older (50–80 yrs) healthy, untrained men and women (BMI: 17–49 kg/m
2
) performed isometric and isokinetic plantar flexor maximum voluntary contractions (MVCs). Volume (
V
m
), fascicle pennation angle (FPA), and physiological cross-sectional area (PCSA) of the
gastrocnemius medialis
(GM) muscle were measured using ultrasonography. Voluntary muscle activation (VA) was assessed using electrical stimulation. GM specific force was calculated as GM fascicle force/PCSA. Percentage body fat (BF%), body fat mass (BFM), and lean mass (BLM) were assessed using dual-energy X-ray absorptiometry. Serum concentration of 12 cytokines was measured using multiplex luminometry.
Results:
Despite greater
V
m
, FPA, and PCSA (
P
<0.05), young individuals with BF% ⩾40 exhibited 37% less GM specific force compared to young BF%<40 (
P
<0.05). Older adults with BF% ⩾40 showed greater isokinetic MVC compared to older BF%<40 (
P
=0.019) but this was reversed when normalised to body mass (
P
<0.001). IL-6 correlated
inversely
with VA in young (
r
=−0.376;
P
=0.022) but not older adults (
p>
0.05), while IL-8 correlated with VA in older but not young adults (
r
⩾0.378,
P
⩽0.027). TNF-alpha correlated with MVC, lean mass, GM FPA and maximum force in older adults (
r
⩾0.458;
P
⩽0.048).
Conclusions:
The age- and adiposity-dependent relationships found here provide evidence that circulating pro-inflammatory cytokines may play different roles in muscle remodelling according to the age and adiposity of the individual.</description><subject>101/1</subject><subject>13/21</subject><subject>631/250/127</subject><subject>631/443/7</subject><subject>692/163/2743/393</subject><subject>692/4023/1671/1668/1973</subject><subject>Absorptiometry, Photon</subject><subject>Adiposity - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Biomechanical Phenomena</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - physiopathology</subject><subject>Internal Medicine</subject><subject>Isometric Contraction</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Muscle strength</subject><subject>Muscle Strength - physiology</subject><subject>Muscle Strength Dynamometer</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Musculoskeletal system</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Older people</subject><subject>Original</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Public Health</subject><subject>Quality of life</subject><subject>Reproducibility of Results</subject><subject>Risk factors</subject><subject>Skeletal muscle</subject><subject>Tumor necrosis factor-TNF</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNks1r3DAQxU1paTZpbz0XQ6HkUG8lW5LlSyCEfkGgl_QsZHm0q60sbS07sNA_vuNsuuyWHIoEAuk3j9Gbl2VvKFlSUsmPbhOXJaFiSTl9li0oq0XBWVM_zxakInVBuOBn2XlKG0II56R8mZ2VNReNkHSR_b5bQ-5C5-5dN2mf69DlJvatC9DlYC2YMeXR5rGF5MZd8QDoFbiwKrBsMoilXRqhdwZ1rNd9r0cXQ457PfU65OkneBhRu5-S8ZBvh7iFYXSQXmUvrPYJXj-eF9mPz5_ubr4Wt9-_fLu5vi0Ml3QsGmObhghqaNuCoYZAJ7qGsYoxqSXQVoIwFVheyrLlmlvBqGW05F0lBatZdZFd7XW3U9tDZyCMg_ZqO7heDzsVtVOnL8Gt1SreK16is7xBgctHgSH-miCNqnfJgPc6QJySopI3TNJS_hfKiajqh7be_YNu4jQEdGKmUK8ROOEDtdIeFFocsUUzi6prnDWvJa8rpJZPULi6eTIxgHV4f1Lw_qhgDdqP6xT9NM8unYIf9qAZYkoD2INvlKg5gQoTqOYEKkwg4m-PvT7AfyOHQLEHEj6FFQxHv35K8A9_tOWB</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Erskine, R M</creator><creator>Tomlinson, D J</creator><creator>Morse, C I</creator><creator>Winwood, K</creator><creator>Hampson, P</creator><creator>Lord, J M</creator><creator>Onambélé, G L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties</title><author>Erskine, R M ; Tomlinson, D J ; Morse, C I ; Winwood, K ; Hampson, P ; Lord, J M ; Onambélé, G L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>101/1</topic><topic>13/21</topic><topic>631/250/127</topic><topic>631/443/7</topic><topic>692/163/2743/393</topic><topic>692/4023/1671/1668/1973</topic><topic>Absorptiometry, Photon</topic><topic>Adiposity - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Biomechanical Phenomena</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - physiopathology</topic><topic>Internal Medicine</topic><topic>Isometric Contraction</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Muscle strength</topic><topic>Muscle Strength - physiology</topic><topic>Muscle Strength Dynamometer</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Musculoskeletal system</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Older people</topic><topic>Original</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Public Health</topic><topic>Quality of life</topic><topic>Reproducibility of Results</topic><topic>Risk factors</topic><topic>Skeletal muscle</topic><topic>Tumor necrosis factor-TNF</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erskine, R M</creatorcontrib><creatorcontrib>Tomlinson, D J</creatorcontrib><creatorcontrib>Morse, C I</creatorcontrib><creatorcontrib>Winwood, K</creatorcontrib><creatorcontrib>Hampson, P</creatorcontrib><creatorcontrib>Lord, J M</creatorcontrib><creatorcontrib>Onambélé, G L</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erskine, R M</au><au>Tomlinson, D J</au><au>Morse, C I</au><au>Winwood, K</au><au>Hampson, P</au><au>Lord, J M</au><au>Onambélé, G L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>41</volume><issue>1</issue><spage>102</spage><epage>111</epage><pages>102-111</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objectives:
The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity.
Subjects/Methods:
Seventy-five young (18–49 yrs) and 67 older (50–80 yrs) healthy, untrained men and women (BMI: 17–49 kg/m
2
) performed isometric and isokinetic plantar flexor maximum voluntary contractions (MVCs). Volume (
V
m
), fascicle pennation angle (FPA), and physiological cross-sectional area (PCSA) of the
gastrocnemius medialis
(GM) muscle were measured using ultrasonography. Voluntary muscle activation (VA) was assessed using electrical stimulation. GM specific force was calculated as GM fascicle force/PCSA. Percentage body fat (BF%), body fat mass (BFM), and lean mass (BLM) were assessed using dual-energy X-ray absorptiometry. Serum concentration of 12 cytokines was measured using multiplex luminometry.
Results:
Despite greater
V
m
, FPA, and PCSA (
P
<0.05), young individuals with BF% ⩾40 exhibited 37% less GM specific force compared to young BF%<40 (
P
<0.05). Older adults with BF% ⩾40 showed greater isokinetic MVC compared to older BF%<40 (
P
=0.019) but this was reversed when normalised to body mass (
P
<0.001). IL-6 correlated
inversely
with VA in young (
r
=−0.376;
P
=0.022) but not older adults (
p>
0.05), while IL-8 correlated with VA in older but not young adults (
r
⩾0.378,
P
⩽0.027). TNF-alpha correlated with MVC, lean mass, GM FPA and maximum force in older adults (
r
⩾0.458;
P
⩽0.048).
Conclusions:
The age- and adiposity-dependent relationships found here provide evidence that circulating pro-inflammatory cytokines may play different roles in muscle remodelling according to the age and adiposity of the individual.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27569681</pmid><doi>10.1038/ijo.2016.151</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2017-01, Vol.41 (1), p.102-111 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5220159 |
| source | Springer Link; Nature Journals Online |
| subjects | 101/1 13/21 631/250/127 631/443/7 692/163/2743/393 692/4023/1671/1668/1973 Absorptiometry, Photon Adiposity - physiology Adolescent Adult Age Distribution Aged Aged, 80 and over Aging Aging - metabolism Aging - physiology Biomechanical Phenomena Body fat Body mass index Cytokines Cytokines - metabolism Epidemiology Female Health aspects Health care Health Promotion and Disease Prevention Humans Hypothalamus Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - physiopathology Internal Medicine Isometric Contraction Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Muscle strength Muscle Strength - physiology Muscle Strength Dynamometer Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Musculoskeletal system Obesity Obesity - complications Obesity - metabolism Obesity - physiopathology Older people Original original-article Physiological aspects Physiology Public Health Quality of life Reproducibility of Results Risk factors Skeletal muscle Tumor necrosis factor-TNF Young Adult Young adults |
| title | The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-11T19%3A07%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20individual%20and%20combined%20effects%20of%20obesity-%20and%20ageing-induced%20systemic%20inflammation%20on%20human%20skeletal%20muscle%20properties&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Erskine,%20R%20M&rft.date=2017-01-01&rft.volume=41&rft.issue=1&rft.spage=102&rft.epage=111&rft.pages=102-111&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/ijo.2016.151&rft_dat=%3Cgale_pubme%3EA476578573%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c581t-9cf99061c1bbec1c0ed6d9443448a8e1b8e6c3ef5282b5a5f641f4125d3864743%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1854819610&rft_id=info:pmid/27569681&rft_galeid=A476578573&rfr_iscdi=true |