Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved s...

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Bibliographic Details
Published in:Scientific reports 2017-01, Vol.7 (1), p.39889-39889, Article 39889
Main Authors: Zhu, Hua, Xiong, Yi, Xia, Yunqiu, Zhang, Rong, Tian, Daiyin, Wang, Ting, Dai, Jihong, Wang, Lijia, Yao, Hongbing, Jiang, Hong, Yang, Ke, Liu, Enmei, Shi, Yujun, Fu, Zhou, Gao, Li, Zou, Lin
Format: Article
Language:English
Subjects:
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Bioinformatics
Granulocyte-macrophage colony-stimulating factor
Humanities and Social Sciences
Immunoregulation
Inflammation
Interleukin 10
Interleukin 13
Interleukin 6
Lipopolysaccharides
Lungs
Macrophages
Mesenchymal stem cells
Mesenchyme
multidisciplinary
Paracrine signalling
Prostaglandin E2
Respiratory distress syndrome
Respiratory therapy
Rodents
Science
Science (multidisciplinary)
Stem cell transplantation
Stem cells
Trachea
Umbilical cord
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Summary:The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep39889