Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration

Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3(-/-) satellite cells mis...

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Bibliographic Details
Published in:Genes & development 2004-09, Vol.18 (18), p.2231-2236
Main Authors: Cornelison, D D W, Wilcox-Adelman, Sarah A, Goetinck, Paul F, Rauvala, Heikki, Rapraeger, Alan C, Olwin, Bradley B
Format: Article
Language:English
Subjects:
Animals
Cell Division - genetics
Cells, Cultured
Female
Gene Expression Regulation, Developmental
Membrane Glycoproteins - genetics
Membrane Glycoproteins - physiology
Mice
Mice, Mutant Strains
Muscle Development - physiology
Muscle Fibers, Skeletal - pathology
Muscle Fibers, Skeletal - physiology
Muscle, Skeletal - growth & development
Muscle, Skeletal - physiology
Muscular Dystrophies - genetics
Muscular Dystrophies - physiopathology
MyoD Protein - metabolism
Proteoglycans - genetics
Proteoglycans - physiology
Regeneration - genetics
Research Communications
Satellite Cells, Skeletal Muscle - pathology
Syndecan-3
Syndecan-4
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Summary:Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3(-/-) satellite cells mislocalize MyoD, differentiate aberrantly, and exhibit a general increase in overall tyrosine phosphorylation. Following induced regeneration, the hyperplastic phenotype is recapitulated. While there are fewer apparent defects in syndecan-4(-/-) muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation. Further, syndecan-4(-/-) satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1214204