Neuroinflammatory and morphological changes in late-life depression: the NIMROD study

We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood tak...

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Bibliographic Details
Published in:British journal of psychiatry 2016-12, Vol.209 (6), p.525-526
Main Authors: Su, Li, Faluyi, Yetunde O., Hong, Young T., Fryer, Tim D., Mak, Elijah, Gabel, Silvy, Hayes, Lawrence, Soteriades, Soteris, Williams, Guy B., Arnold, Robert, Passamonti, Luca, Rodríguez, Patricia Vázquez, Surendranathan, Ajenthan, Bevan-Jones, Richard W., Coles, Jonathan, Aigbirhio, Franklin, Rowe, James B., O'Brien, John T.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
C-Reactive Protein - analysis
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - immunology
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Depressive Disorder, Major - blood
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - immunology
Depressive Disorder, Major - pathology
Female
Hippocampus - diagnostic imaging
Hippocampus - immunology
Hippocampus - metabolism
Hippocampus - pathology
Humans
Inflammation - diagnostic imaging
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Magnetic Resonance Imaging
Male
Multimodal Imaging
Positron-Emission Tomography
Receptors, GABA - metabolism
Short Report
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Summary:We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
ISSN:0007-1250
1472-1465
1472-1465
DOI:10.1192/bjp.bp.116.190165