Current state of knowledge of hepatic encephalopathy (part III): non-absorbable disaccharides

Nonabsorbable disaccharides have been the mainstay of treatment for hepatic encephalopathy since introduced into clinical practice in 1966. Their beneficial effects reflect their ability to reduce the intestinal production/absorption of ammonia. A recent Cochrane review confirmed the efficacy and sa...

Full description

Saved in:
Bibliographic Details
Published in:Metabolic brain disease 2016-12, Vol.31 (6), p.1361-1364
Main Author: Morgan, Marsha Y.
Format: Article
Language:English
Subjects:
Ammonia - antagonists & inhibitors
Ammonia - metabolism
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Disaccharides - pharmacology
Disaccharides - therapeutic use
Gastrointestinal Agents - pharmacology
Gastrointestinal Agents - therapeutic use
Health Knowledge, Attitudes, Practice
Hepatic Encephalopathy - drug therapy
Hepatic Encephalopathy - metabolism
Humans
Intestinal Absorption - drug effects
Intestinal Absorption - physiology
Lactulose - pharmacology
Lactulose - therapeutic use
Metabolic Diseases
Neurology
Neurosciences
Oncology
Original
Original Article
Randomized Controlled Trials as Topic - methods
Sugar Alcohols - pharmacology
Sugar Alcohols - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nonabsorbable disaccharides have been the mainstay of treatment for hepatic encephalopathy since introduced into clinical practice in 1966. Their beneficial effects reflect their ability to reduce the intestinal production/absorption of ammonia. A recent Cochrane review confirmed the efficacy and safety of nonabsorbable disaccharides for the treatment and prevention of hepatic encephalopathy in patients with cirrhosis. The findings were robust and support the use of nonabsorbable disaccharides as a first line treatment for hepatic encephalopathy, in this patient population, and for its prevention.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-016-9910-2