Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016

We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has no...

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Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2016-08, Vol.21 (34), p.1
Main Authors: Tang, Julian W, Holmes, Christopher W, Elsanousi, Fadwa A, Patel, Ayushi, Adam, Fazila, Speight, Rachel, Shenoy, Savitha, Bronnert, Daniel, Stiefel, Gary, Sundaram, Premkumar, Pande, Suchandra, Sridhar, Arani, Kairamkonda, Venkatesh, Bandi, Srini
Format: Article
Language:English
Subjects:
Body fluids
Cerebrospinal Fluid - virology
Female
Genotype
Hospitalization
Humans
Infant
Infant, Newborn
Length of Stay - statistics & numerical data
Male
Newborn babies
Parechovirus - genetics
Parechovirus - isolation & purification
Picornaviridae Infections - diagnosis
Picornaviridae Infections - epidemiology
Picornaviridae Infections - virology
Polymerase chain reaction
Rapid Communication
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Sepsis
Sepsis - epidemiology
Sepsis - virology
Sequence Analysis, DNA
United Kingdom - epidemiology
Viral infections
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Summary:We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has not been routinely included in many in-house and commercial PCR assays for CSF testing. Clinicians should consider routine parechovirus testing in young children presenting with sepsis.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.es.2016.21.34.30326