Paraprotein-Related Kidney Disease: Diagnosing and Treating Monoclonal Gammopathy of Renal Significance

Paraprotein-related kidney disease represents a complex group of diseases caused by an abnormal paraprotein secreted by a clone of B cells. The disease manifestations range from tubulopathies, such as the Fanconi syndrome, to a spectrum of glomerular diseases that can present with varying degrees of...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2016-12, Vol.11 (12), p.2280-2287
Main Authors: Rosner, Mitchell H, Edeani, Amaka, Yanagita, Motoko, Glezerman, Ilya G, Leung, Nelson
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biopsy
Humans
Kidney - pathology
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Kidney Diseases - pathology
Moving Points in Nephrology
Paraproteinemias - complications
Paraproteinemias - therapy
Stem Cell Transplantation
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Summary:Paraprotein-related kidney disease represents a complex group of diseases caused by an abnormal paraprotein secreted by a clone of B cells. The disease manifestations range from tubulopathies, such as the Fanconi syndrome, to a spectrum of glomerular diseases that can present with varying degrees of proteinuria and renal dysfunction. Diagnosis of these diseases can be challenging because of the wide range of manifestations as well as the relatively common finding of a serum paraprotein, especially in elderly patients. Thus, renal biopsy along with detailed hematologic workup is essential to link the presence of the paraprotein to the associated renal disease. Recent advances in treatment with more effective and targeted chemotherapies, as well as stem cell transplantation, have improved the renal and overall prognosis for many of these disorders.
ISSN:1555-9041
1555-905X
DOI:10.2215/cjn.02920316