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Impaired receptivity and decidualization in DHEA-induced PCOS mice
Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low wit...
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Published in: | Scientific reports 2016-12, Vol.6 (1), p.38134-38134, Article 38134 |
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description | Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study. |
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An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep38134</identifier><identifier>PMID: 27924832</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Abortion ; Blastocysts ; Dehydroepiandrosterone ; Embryo transfer ; Embryos ; Endometrium ; Estrogens ; Implantation ; Infertility ; Ovulation ; Polycystic ovary syndrome ; Pregnancy ; Pseudopregnancy ; Stat3 protein ; Sterility ; Uterus</subject><ispartof>Scientific reports, 2016-12, Vol.6 (1), p.38134-38134, Article 38134</ispartof><rights>Copyright Nature Publishing Group Dec 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-73b1070397880552eca7210907613a01bebe4be397da2884a0f076cdea7bd5fc3</citedby><cites>FETCH-LOGICAL-c403t-73b1070397880552eca7210907613a01bebe4be397da2884a0f076cdea7bd5fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1899385632/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1899385632?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27924832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shu-Yun</creatorcontrib><creatorcontrib>Song, Zhuo</creatorcontrib><creatorcontrib>Song, Min-Jie</creatorcontrib><creatorcontrib>Qin, Jia-Wen</creatorcontrib><creatorcontrib>Zhao, Meng-Long</creatorcontrib><creatorcontrib>Yang, Zeng-Ming</creatorcontrib><title>Impaired receptivity and decidualization in DHEA-induced PCOS mice</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. 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An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>27924832</pmid><doi>10.1038/srep38134</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Abortion Blastocysts Dehydroepiandrosterone Embryo transfer Embryos Endometrium Estrogens Implantation Infertility Ovulation Polycystic ovary syndrome Pregnancy Pseudopregnancy Stat3 protein Sterility Uterus |
title | Impaired receptivity and decidualization in DHEA-induced PCOS mice |
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