Impaired receptivity and decidualization in DHEA-induced PCOS mice

Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low wit...

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Bibliographic Details
Published in:Scientific reports 2016-12, Vol.6 (1), p.38134-38134, Article 38134
Main Authors: Li, Shu-Yun, Song, Zhuo, Song, Min-Jie, Qin, Jia-Wen, Zhao, Meng-Long, Yang, Zeng-Ming
Format: Article
Language:English
Subjects:
Abortion
Blastocysts
Dehydroepiandrosterone
Embryo transfer
Embryos
Endometrium
Estrogens
Implantation
Infertility
Ovulation
Polycystic ovary syndrome
Pregnancy
Pseudopregnancy
Stat3 protein
Sterility
Uterus
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Summary:Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep38134