Novel immunotherapy for adult T-cell leukemia/lymphoma: Targeting aurora kinase A

Adult T-cell leukemia/lymphoma is caused by infection with HTLV-1, following a long latent period. Immunotherapy targeting Aurora kinase A, a tumor-associated antigen over-expressed in adult T-cell leukemia/lymphoma, holds great therapeutic potential. We review the evidence in favor of a therapeutic...

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Bibliographic Details
Published in:Oncoimmunology 2016-11, Vol.5 (11), p.e1239006-e1239006
Main Authors: Casey, Nicholas Paul, Fujiwara, Hiroshi, Ochi, Toshiki, Yasukawa, Masaki
Format: Article
Language:English
Subjects:
Adult T-cell leukemia/lymphoma
aurora kinase A
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engineered T cell
immunotherapy
T-cell receptor gene
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Summary:Adult T-cell leukemia/lymphoma is caused by infection with HTLV-1, following a long latent period. Immunotherapy targeting Aurora kinase A, a tumor-associated antigen over-expressed in adult T-cell leukemia/lymphoma, holds great therapeutic potential. We review the evidence in favor of a therapeutic strategy combining vaccination and TCR-gene transfer against this target.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2016.1239006