Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation

Abstract Purpose We examined inflammation as a mediator of associations between bacterial infection markers and gallbladder cancer (GBC). Methods Bacterial response proteins [lipopolysaccharide (LPS), soluble CD14 (sCD14), and LPS-binding protein (LBP)] were measured in 40 GBC cases and 126 gallston...

Full description

Saved in:
Bibliographic Details
Published in:Annals of epidemiology 2016-10, Vol.26 (10), p.704-709
Main Authors: Van Dyke, Alison L., M.D., Ph.D, Kemp, Troy J., Ph.D, Corbel, Amanda F., B.S, Zhu, Bin, Ph.D, Gao, Yu-Tang, M.D, Wang, Bing-Sheng, M.D, Rashid, Asif, M.D., Ph.D, Shen, Ming-Chang, M.D, Hildesheim, Allan, Ph.D, Hsing, Ann W., Ph.D, Pinto, Ligia A., Ph.D, Koshiol, Jill, Ph.D., M.P.H
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Adult
Age Distribution
Biomarkers, Tumor - blood
Carrier Proteins - metabolism
Case-Control Studies
China - epidemiology
Cholecystitis - blood
Cholecystitis - epidemiology
Databases, Factual
Female
Gallbladder cancer
Gallbladder Neoplasms - blood
Gallbladder Neoplasms - epidemiology
Gallbladder Neoplasms - pathology
Humans
Incidence
Inflammation
Internal Medicine
Lipopolysaccharide-pathway
Male
Mediation analysis
Membrane Glycoproteins - metabolism
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Retrospective Studies
Risk Assessment
Sex Distribution
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose We examined inflammation as a mediator of associations between bacterial infection markers and gallbladder cancer (GBC). Methods Bacterial response proteins [lipopolysaccharide (LPS), soluble CD14 (sCD14), and LPS-binding protein (LBP)] were measured in 40 GBC cases and 126 gallstone controls with data on 63 serum inflammation markers. The relationships of LPS, LBP, and sCD14 with GBC were examined by logistic regression, which also was used to evaluate whether these associations are influenced by systemic inflammation as measured by a combinatorial inflammation score. Results The third versus the first tertiles of sCD14 and of LBP were associated with an increased GBC risk [Odds Ratio (95% Confidence Interval): 5.41 (2.00-16.75) for sCD14, and 6.49 (2.24-23.79) for LBP]. sCD14 and LBP were strongly associated with inflammation score (above versus below the median), which itself was associated with a >21-fold increased risk of GBC for the third vs. first tertiles. Associations between GBC and sCD14 and LBP were markedly attenuated when the inflammation score was included in the model. While LPS was not associated with GBC or inflammation, only 35% of cases and 22% of controls had detectable levels. Conclusions These findings suggest that these LPS-pathway proteins are associated with GBC via inflammation-related pathways.
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2016.08.009