Follow-up after focal therapy in renal masses: an international multidisciplinary Delphi consensus project

Purpose To establish consensus on follow-up (FU) after focal therapy (FT) in renal masses. To formulate recommendations to aid in clinical practice and research. Methods Key topics and questions for consensus were identified from a systematic literature research. A Web-based questionnaire was distri...

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Bibliographic Details
Published in:World journal of urology 2016-12, Vol.34 (12), p.1657-1665
Main Authors: Zondervan, P. J., Wagstaff, P. G. K., Desai, M. M., de Bruin, D. M., Fraga, A. F., Hadaschik, B. A., Köllermann, J., Liehr, U. B., Pahernik, S. A., Schlemmer, H. P., Wendler, J. J., Algaba, F., de la Rosette, J. J. M. C. H., Laguna Pes, M. P.
Format: Article
Language:English
Subjects:
Combined Modality Therapy
Consensus
Delphi Technique
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Nephrology
Oncology
Original
Original Article
Prostatic Neoplasms - therapy
Surveys and Questionnaires
Urology
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Summary:Purpose To establish consensus on follow-up (FU) after focal therapy (FT) in renal masses. To formulate recommendations to aid in clinical practice and research. Methods Key topics and questions for consensus were identified from a systematic literature research. A Web-based questionnaire was distributed among participants selected based on their contribution to the literature and/or known expertise. Three rounds according to the Delphi method were performed online. Final discussion was conducted during the “8th International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer” among an international multidisciplinary expert panel. Results Sixty-two participants completed all three rounds of the online questionnaire. The panel recommended a minimum follow-up of 5 years, preferably extended to 10 years. The first FU was recommended at 3 months, with at least two imaging studies in the first year. Imaging was recommended biannually during the second year and annually thereafter. The panel recommended FU by means of CT scan with slice thickness ≤3 mm (at least three phases with excretory phase if suspicion of collecting system involvement) or mpMRI. Annual checkup for pulmonary metastasis by CT thorax was advised. Outside study protocols, biopsy during follow-up should only be performed in case of suspicion of residual/persistent disease or radiological recurrence. Conclusions The consensus led to clear FU recommendations after FT of renal masses supported by a multidisciplinary expert panel. In spite of the low level of evidence, these recommendations can guide clinicians and create uniformity in the follow-up practice and for clinical research purposes.
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-016-1828-0