Repeated recall and PKMζ maintain fear memories in juvenile rats

We examined the neural substrates of fear memory formation and maintenance when repeated recall was used to prevent forgetting in young animals. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after condi...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2016-12, Vol.23 (12), p.710-713
Main Authors: Oliver, Chicora F, Kabitzke, Patricia, Serrano, Peter, Egan, Laura J, Barr, Gordon A, Shair, Harry N, Wiedenmayer, Christoph
Format: Article
Language:English
Subjects:
Aging - metabolism
Aging - psychology
Amygdala - enzymology
Animals
Brief Communication
Fear - physiology
Female
Freezing Reaction, Cataleptic - physiology
Hippocampus - enzymology
Male
Memory Consolidation - physiology
Mental Recall - physiology
Olfactory Perception - physiology
Predatory Behavior
Protein Kinase C - metabolism
Rats, Long-Evans
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Summary:We examined the neural substrates of fear memory formation and maintenance when repeated recall was used to prevent forgetting in young animals. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after conditioning restored contextual fear responses in juveniles 7 d after initial training. In juveniles that received reconsolidation sessions, protein kinase M zeta (PKMζ) increased in the amygdala, but not in the hippocampus. These data suggest that repeated reminders and increased PKMζ maintain fear responses in juvenile animals that otherwise would not exhibit this behavior.
ISSN:1549-5485
1072-0502
1549-5485
DOI:10.1101/lm.042549.116