Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women

Prior studies have only considered one measurement of physical performance in its relationship to fractures and mortality. A single measurement is susceptible to large within-person changes over time, and thus, may not capture the true association between physical performance and the outcomes of int...

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Bibliographic Details
Published in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2016-12, Vol.71 (12), p.1609-1615
Main Authors:	Barbour, Kamil E, Lui, Li-Yung, McCulloch, Charles E, Ensrud, Kristine E, Cawthon, Peggy M, Yaffe, Kristine, Barnes, Deborah E, Fredman, Lisa, Newman, Anne B, Cummings, Steven R, Cauley, Jane A
Format:	Article
Language:	eng
Subjects:	Aged Confounding Factors, Epidemiologic Female Fractures Geriatric Assessment Gerontology Hip Fractures - epidemiology Humans Lower Extremity - physiopathology Mobility Limitation Mortality Mortality - trends Osteoporosis Physical fitness Prospective Studies Risk Factors United States - epidemiology Walking Walking Speed Womens health
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Summary:	Prior studies have only considered one measurement of physical performance in its relationship to fractures and mortality. A single measurement is susceptible to large within-person changes over time, and thus, may not capture the true association between physical performance and the outcomes of interest. Using data from the Study of Osteoporotic Fractures, we followed 7,015 women enrolled prior to age 80 years who had outcome information beyond this age. Trajectories of walking speed (m/s) and chair stand speed (stands/s) were estimated up to the last visit prior to age 80 years using mixed-effects linear regression. Physical performance at age 80 (PF_age80) was assessed at the last visit prior to age 80 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression and multivariate models adjusted for all other covariates. Greatest walking speed decline and chair stand speed decline were both associated with higher risk of hip fracture (HR: 1.28; 95% CI: 1.03, 1.58 and HR: 1.26; 95% CI: 1.03, 1.54, respectively), but not nonspine fractures. Greatest walking speed decline and chair stand speed decline were both associated with a significant 29% (95% CI: 17-42%) and 27% (95% CI: 15-39%) increased risk of mortality, respectively. Greatest declines in walking speed and chair stand speed were both associated with an increased risk of hip fracture and mortality independent of PF_age80 and other important confounders. Both physical performance change and the single physical performance measurement should be considered in the etiology of hip fracture and mortality.
ISSN:	1079-5006 1758-535X