Insulin-induced autoimmune syndrome: A case report

Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinemic hypoglycemia associated with autoantibodies against endogenous insulin. A 56-year-old man was admitted to Ningbo First Hospital for the treatment of spontaneous hypoglycemia. He was found to have elevated fasting insuli...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2016-11, Vol.12 (5), p.3359-3362
Main Authors: Chu, Jian-Ping, Zheng, Xiao-Wei, Lu, Jie, Zhong, Jin-Yan, Li, Jia-Lin, Xu, Miao, Lin, Fang
Format: Article
Language:English
Subjects:
Antigens
Autoimmune diseases
Binding sites
Care and treatment
Case reports
Cholesterol
Complications and side effects
continuous glucose monitoring system
Development and progression
Diabetic neuropathy
Drug dosages
Family medical history
Glucose
Glucose monitoring
Hospitals
Hypoglycemia
Immunoglobulins
Insulin
insulin autoantibodies
insulin autoimmune syndrome
Insulin resistance
Laboratories
Patients
Peptides
Tumors
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Summary:Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinemic hypoglycemia associated with autoantibodies against endogenous insulin. A 56-year-old man was admitted to Ningbo First Hospital for the treatment of spontaneous hypoglycemia. He was found to have elevated fasting insulin level (>1,000 mIU/l) and presence of insulin autoantibodies, and after appropriate workup, was diagnosed with IAS. After treating with prednisone for 2 months, his insulin level started decreasing. In patients with repeated hypoglycemia, IAS should be considered in the differential diagnosis. Prednisone may be effective for the treatment of hypoglycemia in patients with IAS.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3767