STAT4 gene polymorphism in patients after renal allograft transplantation

STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. T...

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Bibliographic Details
Published in:Central-European journal of immunology 2016-01, Vol.41 (3), p.255-259
Main Authors: Dąbrowska-Żamojcin, Ewa, Dziedziejko, Violetta, Safranow, Krzysztof, Domański, Leszek, Słuczanowska-Głabowska, Sylwia, Pawlik, Andrzej
Format: Article
Language:English
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Clinical Immunology
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Summary:STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts. A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays. There were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation. Our results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population.
ISSN:1426-3912
1644-4124
DOI:10.5114/ceji.2016.63124