The incidence rate and characteristics of clinically diagnosed defecatory disorders in the community

Background Defecatory disorders (DD) are defined by clinical and objective features of impaired rectal evacuation. The epidemiology of DD in the population is unknown, partly because many constipated patients do not undergo anorectal tests. Our objectives were to estimate the incidence rate and clin...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2016-11, Vol.28 (11), p.1690-1697
Main Authors: Noelting, J., Eaton, J. E., Choung, R. S., Zinsmeister, A. R., Locke, G. R., Bharucha, A. E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
constipation
Constipation - diagnosis
Constipation - epidemiology
Constipation - physiopathology
defecation
Defecation - physiology
defecography
Defecography - trends
Electronic Health Records - trends
Fecal Incontinence - diagnosis
Fecal Incontinence - epidemiology
Fecal Incontinence - physiopathology
Female
Humans
Incidence
Independent Living - trends
Irritable Bowel Syndrome - diagnosis
Irritable Bowel Syndrome - epidemiology
Irritable Bowel Syndrome - physiopathology
Male
Manometry - trends
Middle Aged
Minnesota - epidemiology
Young Adult
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Summary:Background Defecatory disorders (DD) are defined by clinical and objective features of impaired rectal evacuation. The epidemiology of DD in the population is unknown, partly because many constipated patients do not undergo anorectal tests. Our objectives were to estimate the incidence rate and clinical features of DD in the community. Methods We reviewed the medical records of all patients older than 16 years in Olmsted County, MN, who had constipation and underwent anorectal manometry from 1999 through 2008. Criteria for diagnosing DD were constipation for 6 months or longer and one of the following: (i) abnormal rectal balloon expulsion test; (ii) reduced or increased perineal descent; or (iii) two or more abnormal features with defecography or surface electromyography. Key Results Of 11 112 constipated patients, 516 had undergone anorectal tests; 245 of these (209 women, 36 men) had a DD. The mean (±SD) age at diagnosis was 44 years (±18) among women and 49 years (±19) among men. The overall age‐ and sex‐adjusted incidence rate per 100 000 person‐years was 19.3 (95% CI: 16.8–21.8). The age‐adjusted incidence per 100 000 person‐years was greater (p < 0.0001) in women (31.8, 95% CI: 27.4–36.1) than in men (6.6, 95% CI: 4.4–8.9). Prior to the diagnosis of DD, nearly 30% of patients had irritable bowel syndrome (IBS), 48% had a psychiatric diagnosis, 18% had a history of abuse, and 21% reported urinary and/or fecal incontinence. Conclusions & Inferences Among constipated patients, DD are fourfold more common in women than men and often associated with IBS and psychiatric diagnoses. The overall age‐ and sex‐adjusted incidence rate of defecatory disorders in Olmsted County between 1999 and 2008 was 19.3 per 100 000 person‐years (95% CI: 16.8–21.8), which is greater than the incidence of Crohn's disease but less than that of irritable bowel syndrome (IBS). Defecatory disorders are more common in women and are frequently associated with psychiatric conditions and IBS.
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.12868