Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis

Sphingolipids (SL) are both fundamental structural components of the eukaryotic membranes and signaling molecules that regulate a variety of biological functions. The highly-bioactive lipids, ceramide and sphingosine-1-phosphate, have emerged as important regulators of cardiovascular function in hea...

Full description

Saved in:
Bibliographic Details
Published in:Trends in endocrinology and metabolism 2016-11, Vol.27 (11), p.807-819
Main Authors: Sasset, Linda, Zhang, Yi, Dunn, Teresa M, Di Lorenzo, Annarita
Format: Article
Language:English
Subjects:
Animals
cardiovascular diseases
Cardiovascular Diseases - metabolism
Endocrinology & Metabolism
Homeostasis
Humans
Lysophospholipids - metabolism
Nogo Proteins - metabolism
Nogo-B
sphingolipids
Sphingolipids - biosynthesis
Sphingolipids - metabolism
Sphingosine - analogs & derivatives
Sphingosine - metabolism
SPT
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sphingolipids (SL) are both fundamental structural components of the eukaryotic membranes and signaling molecules that regulate a variety of biological functions. The highly-bioactive lipids, ceramide and sphingosine-1-phosphate, have emerged as important regulators of cardiovascular function in health and disease. In this review we discuss recent insights into the role of SLs, particularly ceramide and sphingosine-1-phosphate, in the pathophysiology of the cardiovascular system. We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme of de novo SL biosynthesis, with an emphasis on the recently discovered inhibitors of serine palmitoyltransferase, ORMDL and NOGO-B proteins. Understanding the molecular mechanisms regulating this biosynthetic pathway may lead to the development of novel therapeutic approaches for the treatment of cardiovascular diseases.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2016.07.005