Pyoderma gangrenosum after trauma in a dog

A 12-year-old male entire Miniature Pinscher presented with excoriations at various body sites, progressively forming ulcers and enlarging until arrested by treatment. Based on the clinical presentation and histopathological analyses, sterile neutrophilic dermatosis was suspected. Therefore, the dog...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2016, Vol.78(8), pp.1333-1337
Main Authors: NAGATA, Noriyuki, YUKI, Masashi, ASAHINA, Ryota, SAKAI, Hiroki, MAEDA, Sadatoshi
Format: Article
Language:English
Subjects:
Animals
canine
Cytokines
Dog Diseases - diagnosis
Dog Diseases - etiology
Dog Diseases - pathology
Dogs - injuries
Interleukin 8
Interleukin-17 - metabolism
Interleukin-1beta - metabolism
Interleukin-8 - metabolism
Internal Medicine
Leukocytes (neutrophilic)
Male
pathergy
Polymerase chain reaction
Prednisolone
Pyoderma
Pyoderma gangrenosum
Pyoderma Gangrenosum - diagnosis
Pyoderma Gangrenosum - etiology
Pyoderma Gangrenosum - pathology
Pyoderma Gangrenosum - veterinary
Real-Time Polymerase Chain Reaction - veterinary
Skin
Skin - metabolism
Skin - pathology
Skin diseases
Transcription
Trauma
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
Ulcers
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Description
Summary:A 12-year-old male entire Miniature Pinscher presented with excoriations at various body sites, progressively forming ulcers and enlarging until arrested by treatment. Based on the clinical presentation and histopathological analyses, sterile neutrophilic dermatosis was suspected. Therefore, the dog was started on prednisolone. Marked improvement was achieved with prednisolone treatment, suggesting a diagnosis of pyoderma gangrenosum (PG). Transcription levels of cytokine mRNA in lesional skin before and after treatment from this dog were quantified by real-time RT-PCR. Transcription levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-8 and IL-17A were higher in lesional skin before treatment than after treatment. Levels of various cytokines could be increased in lesional skin of dogs with PG as well as in human patients with PG.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.15-0724