Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis

Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign prostatic hyperplasia (BPH) and prostate cancer (Pca) while IL-17E interacting with IL-17RB mig...

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Bibliographic Details
Published in:BMC immunology 2016-10, Vol.17 (1), p.36-36, Article 36
Main Authors: Liu, Yanbo, Yang, Wanguo, Zhao, Lijing, Liang, Zuowen, Shen, Weigao, Hou, Qinlong, Wang, Zhenjiang, Jiang, Jing, Ying, Sun
Format: Article
Language:English
Subjects:
Antibodies - blood
Bladder cancer
Carcinogenesis
Cell receptors
Cells, Cultured
Cystitis - complications
Cystitis - immunology
Development and progression
Gene expression
Gene Expression Regulation
Genetic aspects
Humans
Immunohistochemistry
Immunology
Interleukin-17 - genetics
Interleukin-17 - metabolism
Interleukins
Male
Neutrophils - immunology
Physiological aspects
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Polyps - complications
Polyps - immunology
Prostate - immunology
Prostatic Hyperplasia
Thy-1 Antigens - metabolism
Urinary Bladder Neoplasms - complications
Urinary Bladder Neoplasms - immunology
Urinary Tract - immunology
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Summary:Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign prostatic hyperplasia (BPH) and prostate cancer (Pca) while IL-17E interacting with IL-17RB might have an anti-tumor effect. Using imunohistochemistry, we systemically compared immunoreactivity of ligands (IL-17A, E and F) and receptors (IL-17RA, IL-17RB and IL-17RC) of IL-17 family, infiltration of inflammatory cells and changes of structural cells (fibroblast cells, smooth muscle and vascular endothelial cells) in sections of bladder tissues from subjects with bladder cancer, cystitis and bladder polyp. Compared with subjects with cystitis, immunoreactivity for IL-17A, IL-17 F and IL-17RC was significantly elevated in the group of bladder cancer (p 
ISSN:1471-2172
1471-2172
DOI:10.1186/s12865-016-0174-8