Low Proteolytic Clipping of Histone H3 in Cervical Cancer

Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not...

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Bibliographic Details
Published in:Journal of Cancer 2016-01, Vol.7 (13), p.1856-1860
Main Authors: Sandoval-Basilio, Jorge, Serafín-Higuera, Nicolás, Reyes-Hernandez, Octavio D, Serafín-Higuera, Idanya, Leija-Montoya, Gabriela, Blanco-Morales, Magali, Sierra-Martínez, Monica, Ramos-Mondragon, Roberto, García, Silvia, López-Hernández, Luz Berenice, Yocupicio-Monroy, Martha, Alcaraz-Estrada, Sofia L
Format: Article
Language:English
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Short Research Communication
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Summary:Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not been reported. Using HeLa cells as a model of CC and human samples from patients with CC, we identify that the H3 cleavage was lower in CC compared with control tissue. Additionally, the histone H3 clipping was performed by serine and aspartyl proteases in HeLa cells. These results suggest that histone H3 clipping operates as part of post-translational modification system in CC.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.15605