A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy

Loss-of-function screens are powerful tools for identifying gene contribution in a given biological context. Over the past decade, the RNA interference technology has become a dominant approach in the loss-of-function screen-based gene discovery [1].

Bibliographic Details

Published in:	Cell research 2016-09, Vol.26 (9), p.1067-1070
Main Authors:	Mao, Li, Liu, Chenglin, Wang, Zhen, Niu, Xiaofeng, Xue, Liang, Zhou, Zhilei, Cai, Zhenying, Yu, Meng, Li, Yixue, Wu, Dianqing, Li, Lin
Format:	Article
Language:	English
Subjects:	Animals beta Catenin - analysis beta Catenin - metabolism False Negative Reactions Genome - genetics Indoles L Cells Letter to the Editor Mice
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