Bone Marrow-Derived Progenitor Cells Are Functionally Impaired in Ischemic Heart Disease

To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in pati...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2016-08, Vol.9 (4), p.266-278
Main Authors: Nollet, Evelien, Hoymans, Vicky Y., Rodrigus, Inez R., De Bock, Dina, Dom, Marc, Vanassche, Bruno, Van Hoof, Viviane O. M., Cools, Nathalie, Van Ackeren, Katrijn, Wouters, Kristien, Vermeulen, Katrien, Vrints, Christiaan J., Van Craenenbroeck, Emeline M.
Format: Article
Language:English
Subjects:
Adult
Aged
Alkaline Phosphatase - metabolism
Angiogenic Proteins - genetics
Angiogenic Proteins - metabolism
Biomarkers - blood
Biomedical Engineering and Bioengineering
Biomedicine
Bone Marrow Cells - metabolism
Bone Marrow Cells - pathology
Cardiology
Cardiomyopathies - metabolism
Cardiomyopathies - pathology
Case-Control Studies
Cell Differentiation
Cell Movement
Cells, Cultured
Coronary Artery Disease - metabolism
Coronary Artery Disease - pathology
Cytokines - genetics
Cytokines - metabolism
Endothelial Progenitor Cells - metabolism
Endothelial Progenitor Cells - pathology
Female
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - pathology
Human Genetics
Humans
Inflammation Mediators - metabolism
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Ischemia - metabolism
Myocardial Ischemia - pathology
Original
Original Article
Phenotype
Receptors, Cytokine - genetics
Receptors, Cytokine - metabolism
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Summary:To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in patients with coronary artery disease ( n  = 17), HF due to ischemic cardiomyopathy ( n  = 8), non-ischemic HF ( n  = 7), and control subjects ( n  = 11). Myeloid and erythroid differentiation capacity of BM-derived mononuclear cells was impaired in patients with underlying IHD but not with non-ischemic HF. Migration capacity decreased with increasing IHD severity. Hence, IHD, with or without associated cardiomyopathy, is an important determinant of progenitor cell function. No depletion of hematopoietic and endothelial progenitor cells (EPC) within the BM was observed, while circulating EPC numbers were increased in the presence of IHD, suggesting active recruitment. The observed myelosuppression was not driven by inflammation and thus other mechanisms are at play.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-016-9707-z