Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an...

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Bibliographic Details
Published in:Biomedical optics express 2016-09, Vol.7 (9), p.3390-3402
Main Authors: Liu, Mengyang, Chen, Zhe, Zabihian, Behrooz, Sinz, Christoph, Zhang, Edward, Beard, Paul C, Ginner, Laurin, Hoover, Erich, Minneman, Micheal P, Leitgeb, Rainer A, Kittler, Harald, Drexler, Wolfgang
Format: Article
Language:English
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Summary:Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive human skin vasculature and morphology imaging .
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.7.003390