Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats

This study examined sustained co-delivery of vascular endothelial growth factor (VEGF), angiopoietin-1 and basic fibroblast growth factor (bFGF) encapsulated in angiogenic microspheres. These spheres were delivered to sites of spinal cord contusion injury in rats, and their ability to induce vessel...

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Bibliographic Details
Published in:Scientific reports 2016-09, Vol.6 (1), p.33428-33428, Article 33428
Main Authors: Yu, Shukui, Yao, Shenglian, Wen, Yujun, Wang, Ying, Wang, Hao, Xu, Qunyuan
Format: Article
Language:English
Subjects:
Angiogenesis
Angiopoietin
Biodegradability
Enzyme-linked immunosorbent assay
Fibroblast growth factor 2
Microspheres
Motor task performance
Nestin
Neurogenesis
Oligodendrocytes
Polylactide-co-glycolide
Regeneration
Rodents
Spinal cord injuries
Substantia alba
Tubulin
Vascular endothelial growth factor
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Summary:This study examined sustained co-delivery of vascular endothelial growth factor (VEGF), angiopoietin-1 and basic fibroblast growth factor (bFGF) encapsulated in angiogenic microspheres. These spheres were delivered to sites of spinal cord contusion injury in rats, and their ability to induce vessel formation, neural regeneration and improve hindlimb motor function was assessed. At 2-8 weeks after spinal cord injury, ELISA-determined levels of VEGF, angiopoietin-1, and bFGF were significantly higher in spinal cord tissues in rats that received angiogenic microspheres than in those that received empty microspheres. Sites of injury in animals that received angiogenic microspheres also contained greater numbers of isolectin B4-binding vessels and cells positive for nestin or β III-tubulin (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep33428