Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

Highlight ► Using a rat model of perinatal brain injury, we showed that postnatal IL-1Ra, anti-inflammatory treatment, was protective against behavioral deficits and brain injury.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2012-11, Vol.26 (8), p.1331-1339
Main Authors: Girard, Sylvie, Sébire, Hugues, Brochu, Marie-Elsa, Briota, Sinziana, Sarret, Philippe, Sébire, Guillaume
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal models
Animals
Animals, Newborn
Behavior
Brain - drug effects
Brain - immunology
Brain damage
Brain Injuries - drug therapy
Brain injury
Development
Exploratory behavior
Gliosis
Hypoxia
Hypoxia-Ischemia, Brain - drug therapy
Hypoxia-Ischemia, Brain - immunology
IL-1
Inflammation
Inflammation - drug therapy
Inflammation - immunology
Inflammation - metabolism
Interleukin 1
Interleukin 1 receptor antagonist
Interleukin 1 Receptor Antagonist Protein - immunology
Interleukin 1 Receptor Antagonist Protein - therapeutic use
Interleukin-1 - immunology
Interleukin-1 - metabolism
Ischemia
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Myelin
Neonates
Neural stem cells
Neuroprotection
Neuroprotective Agents - therapeutic use
Perinatal exposure
Prenatal experience
Psychiatry
Rats
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Description
Summary:Highlight ► Using a rat model of perinatal brain injury, we showed that postnatal IL-1Ra, anti-inflammatory treatment, was protective against behavioral deficits and brain injury.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2012.09.001