Comparative Approaches to Understanding the Relation Between Aging and Physical Function

Despite dedicated efforts to identify interventions to delay aging, most promising interventions yielding dramatic life-span extension in animal models of aging are often ineffective when translated to clinical trials. This may be due to differences in primary outcomes between species and difficulti...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2016-10, Vol.71 (10), p.1243-1253
Main Authors: Justice, Jamie N, Cesari, Matteo, Seals, Douglas R, Shively, Carol A, Carter, Christy S
Format: Article
Language:English
Subjects:
Aged
Aging
Aging - physiology
Animals
Biomarkers
Biomedical Research - trends
Clinical trials
Disability Evaluation
Geriatric Assessment
Geriatrics
Geriatrics - trends
Haplorhini
Human subjects
Humans
Longevity - physiology
Mice
Models, Animal
Monkeys & apes
Rats
Review in Depth
Rodents
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Summary:Despite dedicated efforts to identify interventions to delay aging, most promising interventions yielding dramatic life-span extension in animal models of aging are often ineffective when translated to clinical trials. This may be due to differences in primary outcomes between species and difficulties in determining the optimal clinical trial paradigms for translation. Measures of physical function, including brief standardized testing batteries, are currently being proposed as biomarkers of aging in humans, are predictive of adverse health events, disability, and mortality, and are commonly used as functional outcomes for clinical trials. Motor outcomes are now being incorporated into preclinical testing, a positive step toward enhancing our ability to translate aging interventions to clinical trials. To further these efforts, we begin a discussion of physical function and disability assessment across species, with special emphasis on mice, rats, monkeys, and man. By understanding how physical function is assessed in humans, we can tailor measurements in animals to better model those outcomes to establish effective, standardized translational functional assessments with aging.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glv035