Identification of Discrete Prognostic Groups in Ewing Sarcoma

Background Although multiple prognostic variables have been proposed for Ewing sarcoma (EWS), little work has been done to further categorize these variables into prognostic groups for risk classification. Procedure We derived initial prognostic groups from 2,124 patients with EWS in the SEER databa...

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Bibliographic Details
Published in:Pediatric blood & cancer 2016-01, Vol.63 (1), p.47-53
Main Authors: Karski, Erin E., McIlvaine, Elizabeth, Segal, Mark R., Krailo, Mark, Grier, Holcombe E., Granowetter, Linda, Womer, Richard B., Meyers, Paul A., Felgenhauer, Judy, Marina, Neyssa, DuBois, Steven G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Bone Neoplasms - classification
Bone Neoplasms - drug therapy
Bone Neoplasms - mortality
Child
Child, Preschool
Clinical trials
Databases, Factual
Etoposide - therapeutic use
Ewing sarcoma
Female
Hematology
Humans
Ifosfamide - therapeutic use
Infant
Infant, Newborn
Kaplan-Meier Estimate
Male
Metastasis
Middle Aged
Oncology
Pediatrics
Prognosis
prognostic groups
recursive partitioning
Sarcoma, Ewing - classification
Sarcoma, Ewing - drug therapy
Sarcoma, Ewing - mortality
SEER Program
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Summary:Background Although multiple prognostic variables have been proposed for Ewing sarcoma (EWS), little work has been done to further categorize these variables into prognostic groups for risk classification. Procedure We derived initial prognostic groups from 2,124 patients with EWS in the SEER database. We constructed a multivariable recursive partitioning model of overall survival using the following covariates: age; stage; race/ethnicity; sex; axial primary; pelvic primary; and bone or soft tissue primary. Based on this model, we identified risk groups and estimated 5‐year overall survival for each group using Kaplan–Meier methods. We then applied these groups to 1,680 patients enrolled on COG clinical trials. Results A multivariable model identified five prognostic groups with significantly different overall survival: (i) localized, age
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25709