Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423

Drug-induced acute kidney injury (AKI) is often encountered in hospitalized patients. Although serum creatinine (SCr) is still routinely used for assessing AKI, it is known to be insensitive and nonspecific. Therefore, our objective was to evaluate kidney injury molecule 1 (KIM-1) in conjunction wit...

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Bibliographic Details

Published in:	Toxicological sciences 2016-07, Vol.152 (1), p.205-213
Main Authors:	Pavkovic, Mira, Robinson-Cohen, Cassianne, Chua, Alicia S, Nicoara, Oana, Cárdenas-González, Mariana, Bijol, Vanesa, Ramachandran, Krithika, Hampson, Lucy, Pirmohamed, Munir, Antoine, Daniel J, Frendl, Gyorgy, Himmelfarb, Jonathan, Waikar, Sushrut S, Vaidya, Vishal S
Format:	Article
Language:	eng
Subjects:	Acetaminophen - adverse effects Acute Kidney Injury - chemically induced Acute Kidney Injury - diagnosis Acute Kidney Injury - genetics Acute Kidney Injury - urine Adult Biomarkers - urine Case-Control Studies Cells, Cultured Cisplatin - adverse effects Cross-Sectional Studies Dose-Response Relationship, Drug Drug Overdose Epithelial Cells - drug effects Epithelial Cells - metabolism Female Hepatitis A Virus Cellular Receptor 1 - analysis Humans Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Longitudinal Studies Male MicroRNAs - genetics MicroRNAs - urine Middle Aged Predictive Value of Tests Time Factors Urinalysis Urinary microRNA Biomarkers of Acute Kidney Injury Young Adult
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