Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies

Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymph...

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Bibliographic Details
Published in:Journal of translational medicine 2016-09, Vol.14 (1), p.252-252, Article 252
Main Authors: Frazzi, Raffaele, Auffray, Charles, Ferrari, Angela, Filippini, Perla, Rutella, Sergio, Cesario, Alfredo
Format: Article
Language:English
Subjects:
Animals
Care and treatment
Diagnosis
Genetic aspects
High-Throughput Nucleotide Sequencing
Humans
Lymphoma - therapy
Lymphoproliferative disorders
Molecular Targeted Therapy
Mutation - genetics
Prognosis
Proteomics
Review
RNA sequencing
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Summary:Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-016-1018-2