Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study

Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular disease. We investigated whether inflammatory and oxidative stress biomarkers linked to cardiovascular disease were...

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Bibliographic Details
Published in:AGE 2016-02, Vol.38 (1), p.1-1, Article 1
Main Authors: Liu, Christine K., Lyass, Asya, Larson, Martin G., Massaro, Joseph M., Wang, Na, D’Agostino, Ralph B., Benjamin, Emelia J., Murabito, Joanne M.
Format: Article
Language:English
Subjects:
Aged
Aging
Aging - metabolism
Biomarkers
Biomarkers - metabolism
Biomass
Biomedical and Life Sciences
Body Mass Index
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cell Biology
Cross-Sectional Studies
Cytokines
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Follow-Up Studies
Frail Elderly
Frailty
Gait
Geriatrics
Geriatrics/Gerontology
Health care
Humans
Incidence
Inflammation
Life Sciences
Male
Medicine
Molecular Medicine
Nephelometry and Turbidimetry
Nutrition research
Odds Ratio
Oxidative stress
Oxidative Stress - physiology
Prospective Studies
Proteins
Public health
Risk Factors
Studies
Time Factors
Tumor necrosis factor-TNF
United States - epidemiology
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Summary:Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular disease. We investigated whether inflammatory and oxidative stress biomarkers linked to cardiovascular disease were associated with frailty and the related outcome of gait speed. We report cross-sectional associations of biomarkers and frailty assessed at Framingham Offspring Study cycle eight. Participants ≥60 years were eligible if they had information on frailty and at least one of the following: C-reactive protein, interleukin-6, tumor necrosis factor receptor 2, 8-epi-FGFα isoprostanes (isoprostanes), lipoprotein phospholipase A2 (LpPLA2) mass or activity, osteoprotegerin, intracellular adhesion molecule-1, monocyte chemoattractant protein-1 or P-selectin. Stepwise logistic models were utilized for frailty and stepwise linear models for gait speed. Covariates included age, sex, body mass index, smoking, and co-morbidities. Odds ratios (ORs) and slope estimates ( B ) are reported per standard deviation increase of log e -transformed biomarker. Of the 1919 participants, 142 (7 %) were frail. In a stepwise model, frailty odds increased with higher interleukin-6 (OR 1.90, 95 % CI 1.51, 2.38), isoprostanes (OR 1.46, 95 % CI 1.12, 1.92), and LpPLA2 mass (OR 1.29, 95 % CI 1.00, 1.65). Stepwise regression found that slower gait speeds were associated with interleukin-6 ( B  = −0.025 m/s, 95 % CI 0.04, −0.01), isoprostanes ( B  = −0.019, 95 % CI −0.03, −0.008), LpPLA2 mass ( B  = −0.016, 95 % CI −0.03, −0.004), and osteoprotegerin ( B  = −0.015, 95 % CI −0.03, −0.002, all p  
ISSN:0161-9152
2509-2715
1574-4647
2509-2723
DOI:10.1007/s11357-015-9864-z