Telocytes and Their Extracellular Vesicles-Evidence and Hypotheses

Entering the new millennium, nobody believed that there was the possibility of discovering a new cellular type. Nevertheless, telocytes (TCs) were described as a novel kind of interstitial cell. Ubiquitously distributed in the extracellular matrix of any tissue, TCs are regarded as cells with telopo...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-08, Vol.17 (8), p.1322-1322
Main Authors: Cretoiu, Dragos, Xu, Jiahong, Xiao, Junjie, Cretoiu, Sanda M
Format: Article
Language:English
Subjects:
Animals
Cellular biology
Exosomes - metabolism
Exosomes - ultrastructure
Extracellular Vesicles - metabolism
Extracellular Vesicles - ultrastructure
Humans
Matrix
Microscopy, Electron, Transmission
Review
Telocytes - cytology
Telocytes - metabolism
Telocytes - ultrastructure
Tissues
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Summary:Entering the new millennium, nobody believed that there was the possibility of discovering a new cellular type. Nevertheless, telocytes (TCs) were described as a novel kind of interstitial cell. Ubiquitously distributed in the extracellular matrix of any tissue, TCs are regarded as cells with telopodes involved in intercellular communication by direct homo- and heterocellular junctions or by extracellular vesicle (EVs) release. Their discovery has aroused the interest of many research groups worldwide, and many researchers regard them as potentially regenerative cells. Given the experience of our laboratory, where these cells were first described, we review the evidence supporting the fact that TCs release EVs, and discuss alternative hypotheses about their future implications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17081322