Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment

The aim of the study was to analyze the effect of ABCB1 genetic polymorphisms on the efficacy of phenytoin (PHT) treatment in epilepsy patients. In total, 200 epilepsy patients who were administered PHT were divided into the responsive and pharmaco-resistance groups depending on the clinical data of...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2016-09, Vol.12 (3), p.1780-1784
Main Authors: Sun, Fei, Cao, Bo-Qiang, Wang, Bo, Wu, Shi-Qiang, Jiang, De-Hua
Format: Article
Language:English
Subjects:
ABCB1 gene
Age
Care and treatment
Chromatography
Deoxyribonucleic acid
DNA
Drug dosages
Drug resistance
Drug therapy
Epilepsy
Equilibrium
Expected values
Flow velocity
Genetic aspects
genetic polymorphism
Genetic polymorphisms
Haplotypes
High performance liquid chromatography
Older people
Phenytoin
Polymorphism
Sodium
Statistical analysis
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Summary:The aim of the study was to analyze the effect of ABCB1 genetic polymorphisms on the efficacy of phenytoin (PHT) treatment in epilepsy patients. In total, 200 epilepsy patients who were administered PHT were divided into the responsive and pharmaco-resistance groups depending on the clinical data of PHT treatment in epilepsy patients. The serum concentration of PHT was detected by high-performance liquid chromatography (HPLC). ABCB1 polymorphisms were analyzed by the polymerase chain reaction restriction-fragment length polymorphism method. The C1236T, C3435T and G2677T/A haplotypes were reconstructed for the ABCB1 gene using SHEsis programs. One-way analysis of variance was used for data analysis. In ABCB1 C1236T, the rate of the CC genotype in pharmaco-resistance (17.5%) was higher than that of the responsive group (2.1%), while the rate of the TT genotype in pharmaco-resistance (41.6%) was lower than that of the responsive group (55.4%) (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3553