A 12-Month–Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response

The ideal dengue vaccine will provide protection against all serotypes of dengue virus and will be economical and uncomplicated in its administration. To determine the ability of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable neutralizing antibody response...

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Bibliographic Details
Published in:The Journal of infectious diseases 2016-09, Vol.214 (6), p.832-835
Main Authors: Durbin, Anna P., Kirkpatrick, Beth D., Pierce, Kristen K., Carmolli, Marya P., Tibery, Cecilia M., Grier, Palmtama L., Hynes, Noreen, Opert, Kari, Jarvis, Adrienne P., Sabundayo, Beulah P., McElvany, Benjamin D., Sendra, Eli A., Larsson, Catherine J., Jo, Matthew, Lovchik, Janece M., Luke, Catherine J., Walsh, Mary C., Fraser, Ellen A., Subbarao, Kanta, Whitehead, Stephen S.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Dengue - immunology
Dengue - prevention & control
Dengue Vaccines - administration & dosage
Dengue Vaccines - adverse effects
Dengue Vaccines - immunology
Dengue virus
Double-Blind Method
Flaviviridae
Humans
Immunization Schedule
Major and Brief Reports
National Institute of Allergy and Infectious Diseases (U.S.)
Placebos - administration & dosage
United States
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - adverse effects
Vaccines, Attenuated - immunology
VIRUSES
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Summary:The ideal dengue vaccine will provide protection against all serotypes of dengue virus and will be economical and uncomplicated in its administration. To determine the ability of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable neutralizing antibody response, a placebocontrolled clinical trial was performed in 48 healthy adults who received 2 doses of vaccine or placebo administered 12 months apart. Evaluation of safety, vaccine viremia, and neutralizing antibody response after each dose indicated that the first dose of vaccine was capable of preventing infection with the second dose, thus indicating that multiple doses are unnecessary.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiw067